Harm from Alzheimer’s Drugs Revealed

Here is another sad example of a medication causing harm, though it did not receive much coverage in the news media.  It’s another reminder that reliance on conventional medicine to fix chronic, inflammatory conditions is not yielding the best results.

Recently, the Journal of the American Medical Association published a review of medications used for Alzheimer’s: cholinesterase inhibitors and memantine, including Aricept and Namenda.  These drugs are used by millions of Americans. They found that the very drugs prescribed for Alzheimer’s actually worsened cognitive decline.

The researchers performed a meta-analysis to examine the data from 10 clinical trials that involved over 2,700 participants.  The analysis showed that patients using either medication had a worse score on their annual Alzheimer’s assessment. It is not surprising then, that Pfizer announced in 2018 that they will cease their research and development of drugs for Alzheimer’s and Parkinson’s. Reports on the failure of Alzheimer’s drugs are becoming common.

In contrast to the poor results of Alzheimer’s drugs, Dr Dale Bredesen at UCLA is publishing evidence of his protocol to reverse cognitive decline and halt the progress of Alzheimer’s disease.  His protocol is known as ReCODE, and involves an extensive analysis of the root causes of brain degeneration, such as chronic infection (root canals, gut dysbiosis) systemic inflammation, uncontrolled blood sugar, insufficient hormones (testosterone, thyroid), nutrient deficiency, and toxic exposures (mold, heavy metals, chemicals). Dr Bredesen has demonstrated that is necessary to address the whole person and all of the risk factors contributing to brain decline, in order to design a precise personalized plan.  

Certainly, one pillar of the ReCODE protocol is a whole foods, low glycemic diet that fights inflammation using vegetables and herbs.  The protocol also incorporates evidence-based supplements like curcumin and DHA. At Rooted & Grounded Wellness, we help clients shift from the typical diet that drives inflammation and insulin resistance, to an anti-inflammatory eating pattern that supports brain health and blood sugar control.  

It has been said that there is no cure for Alzheimer’s Disease.  We are glad that Dr. Bredesen and his team are having success with patients. Taking a proactive stance with diet, exercise, supplements, and reducing toxic exposures is far easier to implement before there is a diagnosis. Contact us so we can help you get started!

Check out a related article: Butyrate and BDNF for Brain Health


Association of Concomitant Use of Cholinesterase Inhibitors or Memantine With Cognitive Decline in Alzheimer Clinical Trials. JAMA Netw Open. 2018;1(7):e184080. doi:10.1001/jamanetworkopen.2018.4080

Reversal of Cognitive Decline: 100 Patients. Bredesen et al., J Alzheimers Dis Parkinsonism 2018, 8:5 DOI: 10.4172/2161-0460.1000450

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